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BRL Abstracts Database |
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Your search for ultrasound produced 3296 results. Page 237 out of 330
| Title |
Stimulation of arteriogenesis in skeletal muscle by microbubble destruction with ultrasound. |
| Author |
Song J Qi M Kaul S Price RJ. |
| Journal |
Circulation |
| Volume |
|
| Year |
2002 |
| Abstract |
BACKGROUND: The application of ultrasound to microbubbles in skeletal muscle creates capillary ruptures. We tested the hypothesis that this bioeffect could be used to stimulate the growth and remodeling of new arterioles via natural repair processes, resulting in an increase in skeletal muscle nutrient blood flow. METHODS AND RESULTS: Pulsed ultrasound (1 MHz) was applied to exposed rat gracilis muscle after intravenous microbubble injection. Capillary rupturing was visually verified by the presence of red blood cells in the muscle, and animals were allowed to recover. Ultrasound-microbubble-treated and contralateral sham-treated muscles were harvested 3, 7, 14, and 28 days later. Arterioles were assessed by smooth muscle alpha-actin staining, and skeletal muscle blood flow was measured with 15- micro m fluorescent microspheres. An approximately 65% increase in arterioles per muscle fiber was noted in treated muscles compared with paired sham-treated control muscles at 7 and 14 days after treatment. This increase in arterioles occurred across all studied diameter ranges at both 7 and 14 days after treatment. Arterioles per muscle fiber in sham-treated and untreated control muscles were comparable, indicating that the surgical intervention itself had no significant effect. Hyperemia nutrient blood flow in treated muscles was increased 57% over that in paired sham-treated control muscles. CONCLUSIONS: Capillary rupturing via microbubble destruction with ultrasound enhances arterioles per muscle fiber, arteriole diameters, and maximum nutrient blood flow in skeletal muscle. This method has the potential to become a clinical tool for stimulating blood flow to organs affected by occlusive vascular disease. |
| Title |
Stimulation of arteriogenesis in skeletal muscle by microbubble destruction with ultrasound. |
| Author |
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| Journal |
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| Abstract |
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| Title |
Stimulation of bone repair by ultrasound. |
| Author |
Dyson M, Brookes M. |
| Journal |
Proc Third Meet World Fed Ultrasound Med Biol - Brighton |
| Volume |
|
| Year |
1982 |
| Abstract |
The repair of fibular fractures has been accelerated and modified by treatment with ultrasound. Complete bilateral transverse fibular fractures were made in adult female Wistar rats. Twelve were maintained as untreated controls. In seventy rats, one fracture was treated with ultrasound and the other mock-irradiated. Ultrasound was delivered at an intensity of 0.5 W cm(^-2) (spatial average, temporal peak), pulsed 2 ms on, 8 ms off for 5 minutes on 4 consecutive days during each week of treatment. The effects of treatment for different combinations of weeks, and at frequencies of 1.5 MHz and 3.0 MHz, were compared microradiographically and histologically. Ultrasonic therapy was most effective when given during the first two weeks after injury, that is, during the inflammatory and early proliferative phases of healing (before hard callus formation). Bone repair tended to be of the juvenile type, involving rapid ossification with little cartilage production when treatment was limited to this period. |
| Title |
Stimulation of healing of varicose ulcers by ultrasound. |
| Author |
Dyson M, Franks C, Suckling J. |
| Journal |
Ultrasonics |
| Volume |
|
| Year |
1976 |
| Abstract |
The local application of theraputic ultrasound has been shown, in a controlled trial, to stimulate the healing of chronic varicose ulcers. The change in ulcer size by the end of the period of treatment was noted. It was found that healing of insonated ulcers was significantly more marked than that exhibited by the controls. |
| Title |
Stimulation of human peripheral neural structures by focused ultrasound. |
| Author |
Gavrilov LR, Gershuni GV, LL'inskii OB, Popova LA, Sirotyuk MG, Tsirul'nikov EM. |
| Journal |
Sov Phys Acoust |
| Volume |
|
| Year |
1974 |
| Abstract |
The authors demonstrate the possibility of stimulating human peripheral neural structures by means of focused ultrasound. The ultrasonic field parameters that could be responsible for the inception of stimulation are discussed. It is shown that the factor eliciting the stimulation of neural structures irradiated with focused ultrasound is the periodic mechanical displacement of the medium. Principles for the design of ultrasonic equipment to be used for the stimulation of neural structures are discussed. |
| Title |
Stimulation of secretion from bovine adrenal chromaffin cells by microsecond bursts of therapeutic levels of ultrasound. |
| Author |
Robinson IM, Kinnick RR, Greenleaf JF, Fernandez JM. |
| Journal |
J Physiol |
| Volume |
|
| Year |
1996 |
| Abstract |
1. In this study the secretory response of individual bovine adrenal chromaffin cells was monitored using amperometric carbon-fibre microelectrodes. Cells were stimulated to secrete by exposure to 20-100 microseconds long tonebursts of ultrasound (2-4 x 10(5) Pa; peak pressure at 1 MHz). 2. Three types of secretory responses were observed: an almost instantaneous response, a delayed release of catecholamines, or a series of 'burst-like' secretory bouts. 3. Fura-2 measurements of intracellular Ca2+ concentrations showed that the release of catecholamines was accompanied by an increase in the intracellular Ca2+ concentration. In the absence of extracellular Ca2+, secretory responses were not evoked showing that Ca2+ entry was necessary to elicit catecholamine release. |
| Title |
Stimulation of tissue regeneration by pulsed plane-wave ultrasound. |
| Author |
Dyson M, Pond JB, Joseph H, Warwick R. |
| Journal |
IEEE Trans Sonics Ultrason |
| Volume |
|
| Year |
1970 |
| Abstract |
Plane-wave ultrasound at certain dosages can cause a statistically significant increase in the rate at which tissue regenerates to replace that lost after injury. The experimental model used in this study is the replacement of tissue in the pinna of the ear of a rabbit after the removal of tissue of area 1 cm2 through the full thickness of the ear. The regenerate consists of skin and its derivatives and elastic cartilage. The method of irradiation and the effects of a range of dosages on the rate of tissue replacement are described. Experimental evidence indicates that the growth rate increases found are not due to thermal effects caused by ultrasound; it is thought that a mechanical factor, streaming, may be involved. Electron microscopic studies show changes in the irradiated tissue that may be interpreted as indicating an increase in protein synthesis and temporary interference with the polymerization of collagen precursors. Autoradiographic investigation of 3H-thymidine uptake shows that the rate of synthesis of DNA in the regenerating tissue is increased by treatment with ultrasound. |
| Title |
Stimulation of tissue repair by ultrasound: A survey of the mechanisms involved. |
| Author |
Dyson M, Suckling J. |
| Journal |
Physiotherapy |
| Volume |
|
| Year |
1978 |
| Abstract |
No abstract available. |
| Title |
Streaming generated by a bubble in an ultrasound field. |
| Author |
Wu J Du G. |
| Journal |
J Acoust Soc Am |
| Volume |
|
| Year |
1997 |
| Abstract |
A theory has been developed to calculate microstreaming velocity inside and outside an isolated air bubble in a liquid produced by a bubble-scattered sound field, taking account of two predominant modes of the bubble's motion: a monopole (pulsation), and a dipole (translational harmonic vibrations). It has been demonstrated that the streaming velocity inside a bubble is much greater than that outside the bubble. It has also been shown that the microstreaming is most pronounced for a bubble undergoing volume resonance, which is in agreement with Elder's experimental observations. If the viscosity of the gas medium in a bubble is neglected in theory, the results obtained agree qualitatively with Davidson and Riley's. |
| Title |
Stress-induced anisotropy in solids the acousto-elastic effect. |
| Author |
Smith RT. |
| Journal |
Ultrasonics |
| Volume |
|
| Year |
1963 |
| Abstract |
In considering the propagation of ultrasound in stressed elastic solids the author is dealing with a fundamental aspect of ultrasonic propagation. He reviews the various theories and compared them with experimental observations and then critically assesses the various methods of measuring velocity, with particular reference to shear wave birefringence. In a long final section he covers the applications of the acousto-elastic effect to a variety of metallurgical problems. |
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