Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
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William D. O'Brien, Jr. publications:

Michael L. Oelze publications:

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Title ARFI ultrasound for in vivo hemostasis assessment postcardiac catheterization, part II: pilot clinical results.
Author Behler RH, Scola MR, Nichols TC, Caughey MC, Fisher MW, Zhu H, Gallippi CM.
Journal Ultrason Imaging
Volume
Year 2009
Abstract In this second of a two part series, we present pilot clinical data demonstrating Acoustic Radiation Force Impulse (ARFI) ultrasound for monitoring the onset of subcutaneous hemostasis at femoral artery puncture sites (arteriotomies), in vivo. We conducted a randomized, reader-blinded investigation of 20 patient volunteers who underwent diagnostic percutaneous coronary catheterization. After sheath removal (6 French), patients were randomized to treatment with either standard of care manual compression alone or, to expedite hemostasis, manual compression augmented with a p-GlcNAc fiber-based hemostatic dressing (Marine Polymer Technologies, Danvers MA). Concurrent with manual compression, serial ARFI imaging began at the time of sheath removal and continued every minute for 15 min. Serial data sets were processed with custom software to (1) estimate the time of hemostasis onset, and (2) render hybrid ARFI/B-Mode images to highlight displacements considered to correspond to extravasted blood. Images were read by an observer blinded to the treatment groups. Average estimated times to hemostasis in patient volunteers treated with manual compression alone (n = 10) and manual compression augmented by hemostatic dressing (n = 9) were, respectively, 13.00 +/- 1.56 and 9.44 +/- 3.09 min, which are statistically significantly different (p = 0.0065, Wilcoxon two-sample test). Example images are shown for three selected patient volunteers. These pilot data suggest that ARFI ultrasound is relevant to monitoring subcutaneous bleeding from femoral arteriotomies clinically and that time to hemostasis was significantly reduced by use of the hemostatic dressing.


Title Arrhythmias in rat hearts exposed to pulsed ultrasound after intravenous injection of a contrast agent.
Author Zachary JF, Hartleben SA, Frizzell LA, O'Brien WD Jr.
Journal J Ultrasound Med
Volume
Year 2002
Abstract To develop an animal model suitable for characterizing electrocardiographic arrhythmias in hearts exposed to ultrasound after injection of a microbubble contrast agent. METHODS: Conduction complex and heart lesion data were recorded from 20 rats that received intravenous injections of 0.25 mL of a contrast agent and were exposed to pulsed ultrasound (frequency, 3.1 MHz; pulse duration, 1.3 microseconds; pulse repetition frequency, 1700 Hz; and in situ peak rarefactional pressure, 15.9 MPa). The volume of the contrast agent based on body weight and the mechanical index (ultrasonic pressure) exceeded those used in echocardiography by 14 to 345 and 3 to 29 times, respectively. RESULTS: Premature atrial complexes, premature ventricular complexes, or polymorphic ventricular tachycardia occurred in 10 rats. When ultrasound exposure was halted, arrhythmias ceased but reoccurred in 4 of the 10 rats when exposure resumed. Myocardial degeneration identified by histochemical staining (hematoxylin-basic fuchsinpicric acid) was observed in 16 rats; however, only 10 rats had arrhythmias. There was no significant difference in the amount of histochemical staining in hearts from rats with arrhythmias when compared with rats without arrhythmias. CONCLUSIONS: An animal model suitable for characterizing electrocardiographic arrhythmias in rat hearts exposed to ultrasound after injection of a microbubble contrast agent was developed. Because arrhythmias were induced principally when the contrast agent interacted with ultrasound during exposure, the presence of myocardial degeneration alone was not a sufficient explanation for ectopic electrical activity. Under these extreme exposure conditions, the data suggest that pulsed ultrasound through its biomechanical interactions with contrast agents has the potential to induce arrhythmias.


Title Arrhythmias in rat hearts exposed to pulsed ultrasound after intravenous injection of a contrast agent.
Author Zachary JF, Hartleben SA, Frizzel LA, O'Brien WD Jr.
Journal J Ultrasound Med
Volume
Year 2002
Abstract Objective. To develop an animal model suitable for characterizing electrocardiographic arrhythmias in hearts exposed to ultrasound after injection of a microbubble contrast agent. Methods. Conduction complex and heart lesion data were recorded from 20 rats that received intravenous injections of 0.25 mL of a contrast agent and were exposed to pulsed ultrasound (frequency, 3.1 MHz; pulse duration, 1.3 microseconds; pulse repetition frequency, 1700 Hz; and in situ peak rarefactional pressure, 15.9 MPa). The volume of the contrast agent based on body weight and the mechanical index (ultrasonic pressure) exceeded those used in echocardiography by 14 to 345 and 3 to 29 times, respectively. Results. Premature atrial complexes, premature ventricular complexes, or polymorphic ventricular tachycardia occurred in 10 rats. When ultrasound exposure was halted, arrhythmias ceased but reoccurred in 4 of the 10 rats when exposure resumed. Myocardial degeneration identified by histochemical staining (hematoxylin-basic fuchsin-picric acid) was observed in 16 rats; however, only 10 rats had arrhythmias. There was no significant difference in the amount of histochemical staining in hearts from rats with arrhythmias when compared with rats without arrhythmias. Conclusions. An animal model suitable for characterizing electrocardiographic arrhythmias in rat hearts exposed to ultrasound after injection of a microbubble contrast agent was developed. Because arrhythmias were induced principally when the contrast agent interacted with ultrasound during exposure, the presence of myocardial degeneration alone was not a sufficient explanation for ectopic electrical activity. Under these extreme exposure conditions, the data suggest that pulsed ultrasound through its biomechanical interactions with contrast agents has the potential to induce arrhythmias.


Title Arterial tissue characterization by intravascular ultrasound radio frequency signal analysis.
Author Ng KH.
Journal Thesis(PhD): Northwestern Univ
Volume
Year 1994
Abstract No Abstract Available.


Title Articular cartilage degeneration classification by means of high-frequency ultrasound
Author Mannicke N, Schone M, Oelze M, Raum K.
Journal Osteoarthr Cartilage
Volume
Year 2014
Abstract Context To date only single ultrasound parameters were regarded in statistical analyses to characterize osteoarthritic changes in articular cartilage and the potential benefit of using parameter combinations for characterization remains unclear. Objective Therefore, the aim of this work was to utilize feature selection and classification of a Mankin subset score (i.e., cartilage surface and cell sub-scores) using ultrasound-based parameter pairs and investigate both classification accuracy and the sensitivity towards different degeneration stages. Design 40 punch biopsies of human cartilage were previously scanned ex vivo with a 40-MHz transducer. Ultrasound-based surface parameters, as well as backscatter and envelope statistics parameters were available. Logistic regression was performed with each unique US parameter pair as predictor and different degeneration stages as response variables. The best ultrasound-based parameter pair for each Mankin subset score value was assessed by highest classification accuracy and utilized in receiver operating characteristics (ROC) analysis. Results The classifications discriminating between early degenerations yielded area under the ROC curve (AUC) values of 0.94–0.99 (mean ± SD: 0.97 ± 0.03). In contrast, classifications among higher Mankin subset scores resulted in lower AUC values: 0.75–0.91 (mean ± SD: 0.84 ± 0.08). Variable sensitivities of the different ultrasound features were observed with respect to different degeneration stages. Conclusions Our results strongly suggest that combinations of high-frequency ultrasound-based parameters exhibit potential to characterize different, particularly very early, degeneration stages of hyaline cartilage. Variable sensitivities towards different degeneration stages suggest that a concurrent estimation of multiple ultrasound-based parameters is diagnostically valuable. In-vivo application of the present findings is conceivable in both minimally invasive arthroscopic ultrasound and high-frequency transcutaneous ultrasound.


Title Artifacts in ultrasound imaging.
Author Kremkau FW, Taylor KJW.
Journal J Ultrasound Med
Volume
Year 1986
Abstract Ultrasound imaging artifacts of acoustic origin relating to resolution, propagation path, and attenuation are reviewed. Lateral and axial resolution limitations are artifactual in nature since a failure to resolve means a loss of detail and two adjacent structures may be visualized as one. Apparent resolution close to the transducer (speckle) is not directly related to tissue texture but is a result of interference effects from the distribution of scatterers in the tissue. Reverberation produces a set of equally spaced artifactual echoes distal to the real reflectors. The mirror image artifact is the presentation of objects that are present on one side of a strong reflector, appearing on the other side as well. Shadowing and enhancement are useful artifacts for determining the nature of masses. Enhancement results from low attenuation objects in sound path while shadowing results from strongly reflecting or strongly attenuating objects. Additional artifacts include section thickness, refraction, multipath, side lobe, grating lobe, focal enhancement, comet tail, ring down, speed error, and range ambiguity.


Title Artifacts in ultrasound imaging.
Author kremkau FW, taylor JW.
Journal J Ultrasound Med
Volume
Year 1986
Abstract Ultrasound imaging artifacts of acoustic origin relating to resolution, propagation path, and attenuation are reviewed. Lateral and axial resolution limitations are artifactual in nature since a failure to resolve means a loss of detail and two adjacent structures may be visualized as one. Apparent resolution close to the transducer (speckle) is not directly related to tissue texture but is a result of interference effects from the distribution of scatterers in the tissue. Reverberation produces a set of equally spaced artifactual echoes distal to the real reflectors. The mirror image artifact is the presentation of objects that are present on one side of a strong reflector, appearing on the other side as well. Shadowing and enhancement are useful artifacts for determining the nature of masses. Enhancement results from low attenuation objects in the sound path while shadowing results from strongly reflecting or strongly attenuating objects. Additional artifacts include section thickness, refraction, multipath, side lobe, grating lobe, focal enhancement, comet tail, ring down, speed error, and range ambiguity.


Title Artificial cavitation nuclei significantly enhance acoustically induced cell transfection.
Author Greenleaf WJ, Bolander ME, Sarkar G, Goldring MB, Greenleaf JF.
Journal Ultrasound Med Biol
Volume
Year 1998
Abstract The efficiency of ultrasound-mediated gene transfection was enhanced three- to four-fold, compared to previous results, through the use of green fluorescent protein reporter gene, cultured immortalized human chondrocytes and artificial cavitation nuclei in the form of Albunex. Cells were exposed to 1.0-MHz ultrasound transmitted through the bottom of six-well culture plates containing immortalized chondrocytes, media, DNA at a concentration of 40 ug/ml and Albunex at 50 x 10(^6) bubbles/mL. Transfection efficiency increased linearly with ultrasound exposure pressure with a transfection threshold observed at a spatial average peak positive pressure (SAPP) of 0.12 MPa and reaching about 50% of the living cells when exposed to 0.41 MPa SAPP for 20 s. Adding fresh Albunex at 50 x 10(^6) bubbles/mL prior to sequential 1-s, 0.32- or 0.41-MPa exposures increased transfection with each exposure, reaching 43% transfection after four exposures. Efficient in vitro and in vivo transfection now appear possible with these enhancements.


Title Assessing the risks for modern diagnostic ultrasound imaging.
Author O'Brien WD Jr.
Journal Jpn J Appl Phys
Volume
Year 1998
Abstract Some 35 years after Paul-Jacques and Pierre Curie discovered piezoelectricity, ultrasonic imaging was developed by Paul Langevin. During this work, ultrasonic energy was observed to have a detrimental biological effect. These observations were confirmed a decade later by R. W. Wood and A. L. Loomis. It was not until the early 1950s that ultrasonic exposure conditions were controlled and specified so that studies could focus on the mechanisms by which ultrasound influenced biological materials. In the late 1940s, pioneering work was initiated to image the human body by ultrasonic techniques. These engineers and physicians were aware of the deleterious ultrasound effects at sufficiently high levels; this endeavored them to keep the exposure levels reasonably low. Over the past three decades, diagnostic ultrasound has become a sophisticated technology. Yet, our understanding of the potential risks has not changed appreciably. It is very encouraging that human injury has never been attributed to clinical practice of diagnostic ultrasound.


Title Assessment of anisotropic tissue elasticity of cortical bone from high-resolution, angular acoustic measurements.
Author Lakshmanan S, Bodi A, Raum K.
Journal IEEE Trans UFFC
Volume
Year 2007
Abstract Assessment of anisotropic elastic properties at the tissue level is still one of the major challenges in bone research. In previous studies, bone sections were cut in different directions relative to a principle axis of symmetry. This causes a high preparation and measurement effort. We have developed a new acoustic scanning procedure that allows one to measure the angular dependence of the acoustic impedance of cylindrically shaped samples (diameter: 4.4 mm) with a single measurement. Our scanning acoustic microscope was equipped with a rotational stage, and a scanning procedure was developed that measures the surface reflection of the rotating cylinder. It was shown in a previous study that the acoustic impedance derived from the reflection coefficient is highly correlated with the elastic coefficient in the probing direction. From the angular reflection, the independent elastic coefficients were derived using assumptions of transverse isotropy and continuum micromechanical model constraints. This method was applied to the inspection of human femoral bone samples. Four cylinders were prepared from the anterior, posterior, medial, and lateral regions. The measurements were performed with a 50 MHz transducer, providing a lateral resolution of 23 mum. Remarkable structural and elastic variations were observed between the four samples. The means and standard deviations of the derived elastic coefficients were: c33 = 29.9 plusmn 5.0 GPa, c11 - 21.9 plusmn 2.1 GPa, C12 = 9.2 plusmn 1.5 GPa, c13 = 9.7 plusmn 1.6 GPa, and c44 = 6.7 plusmn 1.2 GPa. The results demonstrate that microstructural and anisotropic elastic tissue parameters can be assessed by ultrasound in very small bone samples.


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