Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
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William D. O'Brien, Jr. publications:

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Title Interaction of ultrasound with neoplastic tissue. Local effect on subcutaneously implanted Furth-Columbia rat Wilms' tumor.
Author Longo FW, Longo WE, Tomashefsky P, Lattimer JK, Rivin BD, Tannenbaum M.
Journal Urology
Volume
Year 1975
Abstract Ultrasonic irradiation was employed by direct administration to the skin overlying.subcutaneously implanted Furth-Columbia rat Wilms' tumors. Treated tumors were flattened and excavated and demonstrated no stigmata of hemorrhage or infection. There was a marked decrease in growth rate of the tumors with an increase in survival time of the host. Histologic assessment with the light microscope exhibited a sharp line of demarcation between the necrosed sonicated portion of tumor and the viable intact nonsonicated area of tumor. A blackened area of skin, which was not histologically similar to a burn, was interposed betwwen the site of application of the ultrasound and the necrosed tumor.


Title Interaction of ultrasound with neoplastic tissue: IV. alteration of biologic activity in cells derived from rat Wilms' tumor sonicated in vivo.
Author Longo FW, Tomashefsky P, Willhite M, Tannenbaum M.
Journal Urology
Volume
Year 1976
Abstract Paired Wistar-Furth male rats were implanted subcutaneously with the Furth-Columbia rat Wilms' tumor. Seven days after implantation the tumors were either subjected to therapeutic ultrasound irradiation or were left as untreated controls. On the ninth day after implantation the animals were sacrificed, and suspensions of cells were made from the excised tumors by trypsinization. The cells were counted using trypan blue dye as an indicator of viability. New rats were then implanted with cells either from sonicated tumors or cells from controls. In half the.recipient animals the suspensions were matched by total cell count. In the other half of the rats cell counts were matches for viability by the dye exclusion test. Tumors developed in a total of 8 of 11 rats receiving control cells and they died. A palpable tumor did not develop in any rat receiving cells fromsonicated tumors during the ninety-day study period. Surviving rats were challenged with Wilms' tumor by trocar implant. Tumor developed in all recipients, and they died.


Title Interaction of ultrasound with simple biological system.
Author Nyborg WL, Gershoy A, Miller DL.
Journal Proc IPC Sci and Tech Pre
Volume
Year 1977
Abstract No abstract available.


Title Interactions of ultrasound with biological structures.
Author Edmonds PD.
Journal Proc Interact Ultrasound Biol Tissues Workshop - Seattle
Volume
Year 1971
Abstract No abstract available.


Title Interactions of ultrasound with tissues.
Author Hill CR.
Journal Proc Second World Congr Ultrason Med - Rotterdam
Volume
Year 1973
Abstract The interaction mechanisms and their possible effects on tissue are discussed. In addition, the interactions that are made use of in diagnosis, and which involve the encoding, on an ultrasonic beam, of information about a tissue, are considered.


Title Intercellular gas: Its role in sonated plant tissue.
Author Gershoy A, Miller DL, Nyborg WL.
Journal Ultrasound Med
Volume
Year 1976
Abstract No abstract available.


Title Intercomparison of acoustic output measurements of a diagnostic ultrasound.device.
Author Beissner K.
Journal Ultrasound Med Biol
Volume
Year 1999
Abstract An intercomparison of acoustic output measurements with 9 participants from four countries was performed. A commercial.diagnostic ultrasound device including a 3.5-MHz M-mode transducer was circulated for that purpose. The acoustic output of the.device was measured and the temporal-average power output, peak-negative acoustic pressure, output beam intensity, spatial-peak.temporal average derived intensity and arithmetic-mean acoustic-working frequency were determined. Although the majority of.results were in good agreement with one another, there were also some significant deviations from the corresponding grand mean.values, and the overall ranges of the participants' reported measurement results were as follows. Temporal-average power output:.3.8 mW to 9.0 mW; peak-negative acoustic pressure: 1.50 MPa to 2.86 MPa; output beam intensity: 7.3 mW/cm2 to 13.2.mW/cm2; spatial-peak temporal-average derived intensity: 72 mW/cm2 to 176 mW/cm2; arithmetic-mean acoustic-working.frequency: 3.27 MHz to 3.33 MHz. The reasons for the occurrence of significantly low or high values could be identified by the.participants concerned. The results show that correct ultrasonic measurements are not easy to conduct and strongly advise.periodically checking the measurement tools and procedures. .


Title Interferometric determination of ultrasonic absorption in castor oil.
Author Schuele DE, Gutowski FA, Carome EF.
Journal J Acoust Soc Am
Volume
Year 1957
Abstract Observations have been made of the absorption of ultrasound in castor oil at 3 Mc over the temperature range from 10 degrees to 45 degrees C. An improved interferometer system which utilizes a liquid-to-air reflecting interface was employed, together with a simplified electrical detection circuit. The observed absorption is less than the classical values below 25 degrees C, but greater at higher temperatures. In general, the results compare well with those obtained by other observers using different measuring techniques.


Title Interim guidelines on limits of human exposure to airborne ultrasound..
Author International non-ionizing radiation committee of the international radiation protection assoiciation. (Jammet HP, Bosnjakovic BFM, Czerski P, Faber M, Harder D, Marshall J, Repacholi MH, Sliney DH, Villforth JC, Duchene AS).
Journal Health Phys
Volume
Year 1984
Abstract No abstract available.


Title Interlaboratory comparison of backscatter coefficient estimates for tissue-mimicking phantoms.
Author Anderson JJ, Herd MT, King MR, Haak A, Hafez ZT, Song J, Oelze ML, Madsen EL, Zagzebski JA, O'Brien WD Jr, Hall TJ.
Journal Ultrason Imaging
Volume
Year 2010
Abstract Ultrasonic backscatter is useful for characterizing tissues and several groups have reported methods for estimating backscattering properties. Previous interlaboratory comparisons have been made to test the ability to accurately estimate the backscatter coefficient (BSC) by different laboratories around the world. Results of these comparisons showed variability in BSC estimates but were acquired only for a relatively narrow frequency range, and, most importantly, lacked reference to any independent predictions from scattering theory. The goal of this study was to compare Faran-scattering-theory predictions with cooperatively-measured backscatter coefficients for low-attenuating and tissue-like attenuating phantoms containing glass sphere scatterers of different sizes for which BSCs can independently be predicted. Ultrasonic backscatter measurementswere made for frequencies from 1 to 12 MHz. Backscatter coefficients were estimated using two different planar-reflector techniques at two laboratories for two groups of phantoms. Excellent agreement was observed between BSC estimates from both laboratories. In addition, good agreement with the predictions of Faran's theory was obtained, with average fractional (bias) errors ranging from 8-14%. This interlaboratory comparison demonstrates the ability to accurately estimate parameters derived from the BSC, including an effective scatterer size and the acoustic concentration, both of which may prove useful for diagnostic applications of ultrasound tissue characterization.


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