Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
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William D. O'Brien, Jr. publications:

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Title Ultrasound bioeffects and human reproduction.
Author Lele PP.
Journal Ultrasound
Volume
Year 1985
Abstract No abstract available.


Title Ultrasound bioeffects and regulatory issues: an introduction for the echocardiographer.
Author Skorton DJ, Collins SM, Greenleaf JF, Meltzer RS, O'Brien WD Jr, Schnittger I, von Ramm OT.
Journal J Am Soc Echocardiogr
Volume
Year 1988
Abstract Echocardiography is one of the most widely used methods of evaluating diseases of the heart and circulation in adults, children, infants, and fetuses. Many factors are responsible for the extraordinary acceptance of echocardiography throughout the world. Among these factors are the diagnostic efficacy of the method, the relatively low cost of ultrasound imaging equipment (compared with other modalities), the compact size and thus portability of the instrumentation, and the noninvasive nature of the procedure. In addition, an extremely important factor leading to the continued use of echocardiography, particularly in infants and fetuses, is its extraordinarily good safety record. Echocardiography has been in common clinical use for two decades, and during this time there has been no documented evidence of any kind that harm results from clinical examinations. Thus echocardiographers and sonographers commonly consider ultrasound examinations to be without substantial biohazards. Against this backdrop of apparent safety, as defined by widespread clinical experience, it may have come as a surprise to many practitioners to learn of a growing controversy concerning proposed additional regulation of ultrasound imaging equipment as a result of the question of potentially harmful bioeffects from ultrasound. Through its application of surgically, it is well known that high-intensity ultrasound causes damage to biologic tissues; this has been recognized from the earliest experiences with underwater sound ranging. Evidence of bioeffects of ultrasound in vitro and in vivo has more recently been documented under better controlled dosimetric conditions. Evidence of adverse biological effects to humans from ultrasound as used in diagnostic clinical echocardiographic instruments, however, has yet to be demonstrated. Nonetheless, substantial recent adtivity by regulatory agencies has raised concern among manufacturers, practitioners, and patients. What is the basis for this concern? What are the relevant observations, both experimental and clinical, which support the safety versus potential hazards of diagnostic ultrasound? In an attempt to answer questions such as these, the Physics and Instrumentation Committee of the American Society of Echocardiography has prepared this educational document concerning ultrasound bioeffects and echocardiography. In this article we present (1) definitions of some of the physical measurements utilized to characterize the acoustic output of ultrasound instruments; (2) definitions of bioeffects that have been demonstrated in experimental studies (including what is known or speculated concerning their mechanisms); (3) a brief, selective overview of teh literature on bioeffects, including in vitro and in vivo data; and (4) an overview of some of the regulatory issues and processes that affect the manufacture and use of ultrasound imaging systems. Our overall goal is to introduce these concepts to echocardiographers and sonographers so that they may more knowledgeably interpret the increasing amount of information likely to appear in the professional and lay media concerning potential bioeffects of diagnostic ultrasound.


Title Ultrasound bioeffects for the perinatologist.
Author Lewin PA, Goldberg BB.
Journal Gynecol Obstet
Volume
Year 1989
Abstract No abstract available.


Title Ultrasound bioeffects investigations: controls.
Author Cain CA, Dunn F.
Journal Ultrasound Med Biol
Volume
Year 1982
Abstract No abstract available.


Title Ultrasound bioeffects.
Author Porder JB, Porder KN, Meltzer RS.
Journal Echocardiography
Volume
Year 1987
Abstract No abstract available.


Title Ultrasound bioeffects.
Author Gasson MR.
Journal Radiol Today
Volume
Year 1980
Abstract No abstract available.


Title Ultrasound bioeffects: the mechanical and thermal indices.
Author Holland CK.
Journal Book Chapter
Volume
Year 1995
Abstract No abstract available.


Title Ultrasound biologic effects: A suggestion of strain specificity.
Author O'Brien WD Jr, Januzik SJ, Dunn F.
Journal J Ultrasound Med
Volume
Year 1982
Abstract Pregnant hybrid LAF1/J mice were exposed to continuous-wave ultrasonic energy at a frequency of 1 MHz at a spatial peak intensity of either 2.5 W/cm2 or O W/cm2 (sham) for 20 seconds on the eighth day of gestation. Fetal weight (day 18 of gestation) and postpartum pup weight (21, 29 and 42 days post conception) were determined. No significant differences in weight were observed. This result differs from findings in others studies using outbred mouse strains. It is suggested that hybrid mice exposed to ultrasonic energy in utero may be more resistant to alterations in fetal and pup weight progression as compared with outbred strains.


Title Ultrasound breast imaging-the method of choice for examining the young patient.
Author Harper AP, Kelly-Fry E, Noe JS.
Journal Ultrasound Med Biol
Volume
Year 1981
Abstract No abstract available.


Title Ultrasound cardiogram of artificial mitral valves (Starr-Edwards prosthesis).
Author Reid JM, Bor I.
Journal Z Kreislaufforsch
Volume
Year 1969
Abstract No abstract available.


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