Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
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William D. O'Brien, Jr. publications:

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BRL Abstracts Database

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Title Ultrasound contrast for hepatic tumors using IDE particles.
Author Parker KJ, Baggs RB, Lerner RM, Tuthill TA, Violante MR.
Journal Invest Radiol
Volume
Year 1990
Abstract Iodipimide ethyl ester (IDE) can be formulated as dense spherical particles with narrow diameter distribution. When IDE particles are injected intravenously, the Kupffer cells of the hepatic sinusoids accumulate particles within 10 to 20 minutes, after which the clearance and excretion of IDE takes place. During the uptake phase, the dense particles act as scattering sites, increasing the echogenicity of normal liver tissue. In comparison, tumors and other lesions remain at pre-injection echogenicity, as they lack Kupffer cells and therefore do not retain particles. This report provides initial studies of contrast enhancement in rabbit livers with implanted VX2 tumors, scanned in vivo and evaluated ex vivo using pulse-echo techniques. The distribution of particles within hepatic lobules may explain why the observed.echogenicity is greater than that predicted by single-particle backscatter theory. Directions for future improvements are discussed.


Title Ultrasound contrast-detail analysis: A preliminary study in human observer performance.
Author Hall TJ, Insana MF, Soller NM, Harrison LA.
Journal Med Phys
Volume
Year 1993
Abstract No abstract available.


Title Ultrasound contrast-details analysis: A preliminary study in human observer performance.
Author Hall TJ, Insana MF, Soller NM, Harrison LA.
Journal Med Phys
Volume
Year 1993
Abstract Results of a human observer performance study using a new ultrasound contrast-detail (CD) phantom are reported. The new phantom allows estimates of the fundamental statistical uncertainties involved in CD analysis. Results of these experiments show that observers generally considered to be ?trained? require experience at the specific task of low-contrast target detection under signal known exactly (SKE) conditions, and that observers require an orientation period at the beginning of each observation session to obtain stable responses. The results obtained in this study can be used to estimate the number of independent images, observers, and repeat observation sessions required for a desired uncertainty in CD curves, and show that 10% fractional standard deviations are obtainable with modest observer effort.


Title Ultrasound data acquisition system design for collecting high quality RF data from beef carcasses in the slaughterhouse environment.
Author Hein IA, Novakofski JA, O'Brien WD Jr.
Journal Proc Ultrason Symp IEEE
Volume
Year 1992
Abstract Ultrasound has considerable potential to accurately and precisely grade beef. The ultimate goal is an automated and objective grading process. The current phase of the work does not involve construction of an ultrasound grading device but rather the determination of which of these ultrasound-related and derived quantities best correlate to each grade. In order to make this determination, an ultrasound data acquisition system capable of acquiring large amounts of high-quality RF data from beef carcasses has been constructed. The engineering concepts and construction details of an ultrasound data acquisition device to be used as a research tool for this application are presented.


Title Ultrasound detection of cell death.
Author Czarnota GJ, Kolios MC.
Journal Review
Volume
Year 2010
Abstract Ultrasound has been used to detect tissue pathology since the 1960s. Although early studies were limited in terms of their appreciation of biology and the physics of ultrasound backscatter as it related to the biology of cell death, recent investigations combining rigorous and well-controlled biological experimentation and quantitative ultrasound methods have provided valuable information. Studies indicate that ultrasound may be used to detect and potentially quantify cell death in vitro, in situ and in vivo at conventional ultrasound frequencies, higher ultrasound frequencies and using ultrasound microscopy. These studies point to an important role of the cell’s nucleus and its configuration in the formation of ultrasound backscatter in addition to cellular morphology.


Title Ultrasound detection of differences in density: Explanation of the ureteric jet phenomenon and implications for new ultrasound applications.
Author Price CI, Adler RS, Rubin JM.
Journal Invest Radiol
Volume
Year 1989
Abstract Flow of urine from the ureter into the bladder can be encountered during routine sonographic examination of the pelvis. The findings include a stream of hyperechogenic foci spurting into the bladder in real time with the production of a frequency shift during Doppler examination. We have demonstrated that visualization of this phenomenon, at least in part, reflects differences in density and associated compressibility changes between urine in the bladder and in the ureter, and need not be dependent upon flow velocity or other previously hypothesized parameters. The clinical utility of these reproducible and measurable phenomena is explored.


Title Ultrasound determination of total arterial wall thickness.
Author Hodges TC, Detmer PR, Dawson DL, Bergelin RO, Beach KW, Hatsukami TS, Zierler. BK, Isaacson KA, Strandness E Jr.
Journal J Vasc Surg
Volume
Year 1994
Abstract Purpose: Ultrasonic measurement techniques for determining intima-media thickness and total arterial wall thickness have been described. The intima-media thickness measurements are currently in use in large epidemiologic trials. Intima-media thickness does not evaluate extramedial atherosclerotic change and so may not fully reflect pathologic changes in the arterial wall.


Title Ultrasound diagnosis for head injuries.
Author Heimburger RF, Fry FJ, Franklin TD, Eggleton RC.
Journal J Indiana State Med Assoc
Volume
Year 1976
Abstract No abstract available.


Title Ultrasound diagnosis of liver metastases.
Author McArdle CR.
Journal J Clin Ultrasound
Volume
Year 1976
Abstract Twenty-one patients were investigated with ultrasound for the diagnosis of liver metastases.The most common specific appearnces of liver metastases encountered in this series were echogenic nodules and transsonic areas within an echogenic parenchyma. Nonspecific signs include hepatomegaly, distortion of the hepatic outline and alteration of the normal liver architecture. The results of this study suggest that the accuracy of this method of identifying liver metastases may be high.


Title Ultrasound diagnostic techniques in obstetrics and gynecology.
Author Taylor ES, Holmes JH, Thompson HE, Gottesfeld KR.
Journal Am J Obstet Gynecol
Volume
Year 1964
Abstract No abstract available.


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