Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
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William D. O'Brien, Jr. publications:

Michael L. Oelze publications:

Aiguo Han publications:

BRL Abstracts Database

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Title Collagen as a determination of ultrasonic attenuation in myocardial infarcts.
Author O'Donnell M. Miller JG, Sobel BE, Mimbs JW.
Journal Ultrasound Med
Volume
Year 1978
Abstract No abstract available.


Title Colony size and giant cell formation from mammalian cells exposed to 1 MHz ultrasound.
Author Miller MW, Ciaravino V, Kaufman GE.
Journal Radiat Res
Volume
Year 1977
Abstract Chinese hamster ovary (CHO) cells were exposed to continuous wave 1 MHz, 5 W/cm2 ultrasound for 5 min, plated, and allowed to grow for 7 days; colonies were then scored for size and for the presence of giant cells. Sonicated colonies contained fewer cells than controls by a factor of 0.53 (P < 0.001), but contained more giant cells than sham controls by a factor of 1.30 (P < 0.001). On a per cell basis the frequency of giant cells was 2.47 times higher in the colonies arising from sonicated cells. Characteristics of giant cells varied; all were abnormally large cells with one large nucleus or several smaller nuclei and/or protoplasmic bridges.


Title Color flow imaging: understanding its science and technology.
Author Powis RL.
Journal J Diagn Med Sonogr
Volume
Year 1988
Abstract The latest change to occur in diagnostic ultrasound is color flow imaging. This technology presents an image with tissue in gray scale and blood flow in color. Image formation can be asynchronous or synchronous, representing different approaches to data gathering, and consequently different internal signal processing. This article focuses on how these technologies deal with problems in imaging and meeting clinical needs, and establishes the basic parameters needed for clinical vascular imaging.


Title Color-coded differential doppler ultrasonic scanning system for the carotid bifurcation: Results on 486 bifurcations angiographically confirmed.
Author White DN, Curry GR.
Journal Proc Int Symp Recent Adv Ultrasound Diagn - Dubrovnik
Volume
Year 1977
Abstract No abstract available.


Title Combination treatment of ultrasound and drug on tumor.
Author Umemura K, Yumita N, Nishigaki R, Umemura S.
Journal Proc JSUM
Volume
Year 1989
Abstract The antitumor effects of ultrasound (US) and photosensitizer, hematoporphyrin (Hp), ere studied in in vitro and in vivo. Hp alone showed no antitumor effect but US alone showed a little antitumor effect. The combination treatments of US and Hp marked synergistic effects.


Title Combined imaging and therapy with piezocomposite phased arrays.
Author Simon C, VanBaren P, Ebbini E.
Journal Proc Ultrason Symp IEEE
Volume
Year 1998
Abstract Recently, we have developed temperature estimation algorithms based on signal processing of pulse-echo ultrasound radio frequency (rf) data at diagnostic levels. A modified commercially available scanner was used to obtain 2D temperature estimates that were color coded and overlaid on real-time B-scan images to show the location and extent of the therapeutic beam with respect to the target as well as any critical structures in the treatment region. Recent advances in piezocomposite transducer technology have allowed the development of high power phased arrays for high-intesity focused ultrasound (HIFU) generation with excellent cross coupling characteristics. Furthermore, fractional bandwidths of 30 - 60 % are now possible with such arrays. Therefore, we have investigated the feasibility of utilizing a 64-element piezocomposite therapeutic array in an imaging mode. The array is concave on a spherical shell with a radius of curvature of 100 mm with elements arranged in a linear configuration (2 mm x 50 mm). The array operates at a center frequency of 1.25 MHz and has a fractional bandwidth of 37 %. Wire target images as well as images from a tissue mimicking cyst phantom were reconstructed using a synthetic aperture technique. Excellent image quality was achieved in a region extending 70 mm axially and 60 mm laterally and centered around the geometric center of the array. Furthermore, we have experimentally established that the speckle generated by this array can be used to extract temperature information based on our previously described algorithm. This was demonstrated by using a 4 x 64 matrix switch and a high speed digitizer to acquire image frames during a slow heating experiment.


Title Combined radiation and hyperthermia in superifical human tumors.
Author Marmor JB, Hahn GM.
Journal Cancer
Volume
Year 1980
Abstract Hyperthermia (42--43 C) appears to potentiate the effects of radiation therapy in experimental tumor models. In addition, some studies indicate that tumors may be sensitized to a greater extent than normal tissue. This study was designed to test whether the effectiveness of irradiating human tumors was enchanced significantly by concomitant heating. We also examined skin to see if heating enhanced the response to radiation of normal tissues. Nineteen patients with multiple metastatic superficial tumor masses of various histologies were studied. All were considered incurable and an independent clinical decision had been made to irradiate for palliation. Two or more masses in the same patient were matched for size and location, so that one of the patient's own tumors was a control to monitor the effect of irradiation alone. On each patient the tumors were treated with identical fractions and to the same total dose of radiation. One of the matched nodules was given hyperthermia (43 C) for 15 minutes before and 30 minutes after each radiation fraction. The response of the tumor that received radiation alone was compared with that of the tumor receiving hyperthermia and radiation. In seven of 15 evaluable patients the tumor that received heat in addition to radiation had a greater objective response than the tumor receiving radiation alone (P < .065). Of the remaining eight patients, four had complete tumor regression in both areas without later regrowth, two failed to respond in either area, and two partially responded in both areas. Two patients had increased cutaneous reaction to radiation in the heated area; one of these was a severe desquamative reaction, which conformed to the size and shape of the ultrasound field. These results suggest that hyperthermia improves the objective response to radiation in some human tumors; in two cases it appeared to sensitize skin as well.


Title Combined use of mammography and ultrasound visualization using a laboratory-modified commercial breast scanner to improve differential dIagnosis.
Author Harper P, Kelly-Fry E.
Journal Proc 23rd Annual Meeting Am Inst Ultrasound Med
Volume
Year 1978
Abstract No abstract available.


Title Comet assay reveals DNA strand breaks induced by ultrasonic cavitation in vitro.
Author Miller DL, Thomas RM, Buschbom RL.
Journal Ultrasound Med Biol
Volume
Year 1995
Abstract The induction of DNA strand breaks in cultured Chinese hamster ovary (CHO) cells was investigated in suspensions directly exposed to 2.17-MHz ultrasound. Production of hydrogen peroxide, a DNA-damaging sonochemical, by inertial cavitation was enhanced by the use of argon-and-oxygen-bubbled media and cell survival was improved by establishing standing waves and minimizing tube rotation. Viable cells were separated from the suspension after exposure and kept on ice for evaluation with the single-cell gel electrophoresis (comet) assay. With this assay, DNA damage from as little as 2-mumol/L hydrogen peroxide.treatment for 30 min could be detected, and cell survival as low as 2-5% after ultrasound exposure was adequate for assay. An ultrasound dose-response trend was noted for increasing pressure amplitude up to 0.82 MPa (free field) and increasing exposure duration up to 4 min. The cells were able to repair some of the strand breaks when warmed to 28 degrees C for 30 min. The effect was not eliminated by addition of catalase, which indicates that the DNA damage was not due to the action of residual H2O2 alone. The results confirm the hypothesis of DNA damage in cells surviving inertial cavitation.


Title Comment on "Ultrasound-induced lung hemorrhage is not caused by inertial cavitation".
Author Apfel RE.
Journal J Acoust Soc Am
Volume
Year 2001
Abstract This contribution summarizes the reasons for disagreeing with a conclusion by O'Brien et al. [J. Acoust. Soc. Am. 108, 1290-1297 (2000)] that ultrasound-induced lung hemorrhage is not caused by inertial cavitation. An argument is provided that illustrates how cavitation inception conditions in the lungs of animals are not altered significantly if the hydrostatic pressure is increased by increasing the pressure of air that is being breathed by the animal.


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