Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
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William D. O'Brien, Jr. publications:

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Your search for ultrasound produced 3296 results.

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Title Ultrasound mammographic-histopathologic correlation.
Author Fields SI.
Journal Ultrason Imaging
Volume
Year 1980
Abstract A simple technique for the production of ultrasound mammograms employing unmodified commercially available B-scanners has been developed. Specific image criteria of breast lesions were correlated with the histopathologic appearances of the tissue. Special connective tissue stains were employed. The thickness and echogenicity of the breast tumor border was correlated with the level of surrounding collagenosis and tumor invasion. The acoustic attenuation of breast tumors was qualitatively proportional to the amount of collagen within the tumor. The accuracies of specific image crieteria for the diagnosis of carcinoma were determined. Water-lipid interfaces appear to be important in the production of echoes from within breast tissue and at the tumor margin.


Title Ultrasound mammography.
Author Baum G.
Journal Radiology
Volume
Year 1977
Abstract Ultrasound mammography was performed with unique, high resolution equipment which displays changes in acoustic properties of tissues through a calibrated gray scale. Color-coded isodensitometry was used to assist in the differential diagnosis. The rate of agreement between the ultrasound and pathological diagnoses was 86.7%. The false negative and false positive rates were 7.6% and 18.5%, respectively. Three problems must be solved before ultrasound mammography can be used as a screening device: First, additional clinical data must be accumulated. Second, the number of ultrasonograms needed for diagnosis must be reduced..Third, special equipment designed for ultrasound mammography must be developed.


Title Ultrasound measurement of blood flow by time-domain correlation.
Author Suorsa V.
Journal Thesis(PhD): Univ of Oulu
Volume
Year 1991
Abstract A blood flow measurement method based on the time-domain correlation has been developed to the level of in vivo measurements. The time-domain technique calculates the velocity from the time it takes a scatterer, or a group of scatterers, to move a given distance. The time shift between consecutive ultrasound pulses as they become scattered by the moving blood is directly proportional to the flow velocity and it is not affected, for instance, by the frequency-dependent attenuation of ultrasound or by the frequency-dependent scattering of ultrasound from blood.


Title Ultrasound measurements of the left ventricle: A correlative study with angiocardiography.
Author Feigenbaum H, Popp RL, Wolfe SB, Troy BL, Pombo JF, Haine CL, Dodge HT.
Journal Arch Intern Med
Volume
Year 1972
Abstract A technique has been developed for measuring the distance between the interventricular septum and the posterior wall of the left ventricle using pulsed reflected ultrasound. This measurement was labeled left ventricular internal dimension (LVID) and was obtained at end-diastole (LVIDd) and at end-systole (LVIDs). These ultrasound dimensions were compared with angiocardiographic left ventricular volume determinations on 42 patients. The ultrasound LVID correlated well with the corresponding angiographic volume measurements especially when LVID was cubed. The correlation between LVIDd minus LVIDs and left ventricular stroke volume was also highly significant. These initial results are quite promising and suggest that although there remain some unresolved problems and limitations, echo-cardiography ultimately may provide a clinically useful, noninvasive technique for quantitative estimations of left ventricular volumes in man.


Title Ultrasound mediated delivery of drugs and genes to solid tumors.
Author Frenkel V.
Journal Adv Drug Deliv Rev
Volume
Year 2008
Abstract It has long been shown that therapeutic ultrasound can be used effectively to ablate solid tumors, and a variety of cancers are presently being treated in the clinic using these types of ultrasound exposures. There is, however, an ever-increasing body of preclinical literature that demonstrates how ultrasound energy can also be used non-destructively for increasing the efficacy of drugs and genes for improving cancer treatment. In this review, a summary of the most important ultrasound mechanisms will be given with a detailed description of how each one can be employed for a variety of applications. This includes the manner by which acoustic energy deposition can be used to create changes in tissue permeability for enhancing the delivery of conventional agents, as well as for deploying and activating drugs and genes via specially tailored vehicles and formulations.


Title Ultrasound methods for investigating the non-Newtonian characteristics of whole blood.
Author Shehada RE, Cobbold RS, Bascom PA.
Journal IEEE Trans UFFC
Volume
Year 1994
Abstract The development and evaluation of new techniques for investigating the non-Newtonian characteristics of blood are described. Ultrasound B-mode imaging (7 MHz) was used to measure simultaneously the echogenicity and velocity profiles of 28% hematocrit porcine whole blood. Measurements were made at various axial locations in a large diameter (D=2.54 cm) long (>60 D) tube, under steady flow conditions. A block matching (correlation) technique between successive digitized images was used to determine the velocity profiles, and from these, shear rate profiles were calculated. The optimal block dimensions were found to be dependent on the magnitude and direction of the flow shear rate. Echogenicity profiles were determined from ensemble averaged images. It is shown how such profiles in combination with the corresponding shear rate profiles enables information to be obtained concerning the dependence of aggregation on shear rate. Pulsed Doppler ultrasound (20 MHz) was also used to measure the velocity and backscattered power profiles at 60 D from the tube entrance. Velocity profiles measured using B-mode were in good agreement with those obtained using both pulsed Doppler and magnetic resonance imaging and mean velocity errors of less than 5% were achieved..


Title Ultrasound monitoring of hepatic metastases chemotherapy.
Author Gilby ED, Taylor JKW.
Journal Br Med J
Volume
Year 1975
Abstract Grey-scale ultrasonography has been found to be the most sensitive method of detecting metastatic disease of the liver. In two cases the results of chemotherapy were monitored by ultrasound; the response to treatment could be distinguished from non-response and ultrasonography gave useful information when chemotherapy made radioisotope examination unreliable.


Title Ultrasound nakagami imaging:A strategy to visualize the scatterer properties of bengin and malignant breast tumors.
Author Tsui P,Yeh C,Liao Y,Chang C,Kuo W,Chang K,Chen C.
Journal Ultrasound Med Biol
Volume
Year 2009
Abstract Previous studies have demonstrated the usefulness of the Nakagami parameter in characterizing breast tumors by ultrasound. However, physicians or radiologists may need imaging tools in a clinical setting to visually identify the properties of breast tumors. This study proposed the ultrasonic Nakagami image to visualize the scatterer properties of breast tumors and then explored its clinical performance in classifying benign and malignant tumors. Raw data of ultrasonic backscattered signals were collected from 100 patients (50 benign and 50 malignant cases) using a commercial ultrasound scanner with a 7.5 MHz linear array transducer. The backscattered signals were used to form the B-scan and the Nakagami images of breast tumors. For each tumor, the average Nakagami parameter was calculated from the pixel values in the region-of-interest in the Nakagami image. The receiver operating characteristic (ROC) curve was used to evaluate the clinical performance of the Nakagami image. The results showed that the Nakagami image shadings in benign tumors were different from those in malignant cases. The average Nakagami parameters for benign and malignant tumors were 0.69 +/- 0.12 and 0.55 +/- 0.12, respectively. This means that the backscattered signals received from malignant tumors tend to be more pre-Rayleigh distributed than those from benign tumors, corresponding to a more complex scatterer arrangement or composition. The ROC analysis showed that the area under the ROC curve was 0.81 +/- 0.04 and the diagnostic accuracy was 82%, sensitivity was 92% and specificity was 72%. The results showed that the Nakagami image is useful to distinguishing between benign and malignant breast tumors. 2010 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.


Title Ultrasound oculomtry and exophthalmometry in high myopia with reference to the occurrence of retimal detachment.
Author Fledelius H.
Journal Acta Ophthalmol
Volume
Year 1971
Abstract No abstract available.


Title Ultrasound of the fingers for human identification using biometrics.
Author Narayanasamy G, Fowlkes JB, Kripfgans OD, Jacobson JA, Maeseneer MD, Schmitt RM, Carson PL.
Journal Ultrasound Med Biol
Volume
Year 2008
Abstract It was hypothesized that the use of internal finger structure as imaged using commercially available ultrasound (US) scanners could act as a supplement to standard methods of biometric identification, as well as a means of assessing physiological and cardiovascular status. Anatomical structures in the finger including bone contour, tendon and features along the interphalangeal joint were investigated as potential biometric identifiers. Thirty-six pairs of three-dimensional (3D) gray-scale images of second to fourth finger (index, middle and ring) data taken from 20 individuals were spatially registered using MIAMI-FuseĀ© software developed at our institution and also visually matched by four readers. The image-based registration met the criteria for matching successfully in 14 out of 15 image pairs on the same individual and did not meet criteria for matching in any of the 12 image pairs from different subjects, providing a sensitivity and specificity of 0.93 and 1.00, respectively. Visual matching of all image pairs by four readers yielded 96% successful match. Power Doppler imaging was performed to calculate the change in color pixel density due to physical exercise as a surrogate of stress level and to provide basic physiological information.


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