|
|
|
BRL Abstracts Database |
|
Your search for ultrasound produced 3296 results. Page 173 out of 330
| Title |
Measurements of ultrasounic backscattered spectral centroid shift from spine in vivo: Methodology and preliminary results. |
| Author |
Garra BS,Locher M, Felker S,Wear KA. |
| Journal |
Ultrasound Med Biol |
| Volume |
|
| Year |
2009 |
| Abstract |
Ultrasonic backscatter measurements from vertebral bodies (L3 and L4) in nine women were performed using a clinical ultrasonic imaging system. Measurements were made through the abdomen. The location of a vertebra was identified from the bright specular reflection from the vertebral anterior surface. Backscattered signals were gated to isolate signal emanating from the cancellous interiors of vertebrae. The spectral centroid shift of the backscattered signal, which has previously been shown to correlate highly with bone mineral density (BMD) in human calcaneus in vitro, was measured. BMD was also measured in the nine subjects' vertebrae using a clinical bone densitometer. The correlation coefficient between centroid shift and BMD was r = −0.61. The slope of the linear fit was −160 kHz / (g/cm2). The negative slope was expected because the attenuation coefficient (and therefore magnitude of the centroid downshift) is known from previous studies to increase with BMD. The centroid shift may be a useful parameter for characterizing bone in vivo. (E-mail: keith.wear@fda.hhs.gov)
Published by Elseiver Inc. on behalf of World Federation for Ultrasound in Medicine and Biology.
Key Words: Bone; Vertebra; Backscatter
|
| Title |
Measures used in describing the damping of ultrasound. |
| Author |
Gellings PJ. |
| Journal |
Acustica |
| Volume |
|
| Year |
1961 |
| Abstract |
No abstract available. |
| Title |
Mechanical bioeffects of ultrasound. |
| Author |
Dalecki D. |
| Journal |
Annu Rev Biomed Eng |
| Volume |
|
| Year |
2004 |
| Abstract |
Ultrasound is used widely in medicine as both a diagnostic and therapeutic tool. Through both thermal and nonthermal mechanisms, ultrasound can produce a variety of biological effects in tissues in vitro and in vivo. This chapter provides an overview of the fundamentals of key nonthermal mechanisms for the interaction of ultrasound with biological tissues. Several categories of mechanical bioeffects of ultrasound are then reviewed to provide insight on the range of ultrasound bioeffects in vivo, the relevance of these effects to diagnostic imaging, and the potential application of mechanical bioeffects to the design of new therapeutic applications of ultrasound in medicine.
|
| Title |
Mechanism of absorption of ultrasound in liver tissue. |
| Author |
Pauly H, Schwan HP. |
| Journal |
J Acoust Soc Am |
| Volume |
|
| Year |
1971 |
| Abstract |
The dominant part of the acoustic absorption of liver tissue and its components results from macromolecular relaxation processes. The absorption has been investigated over the frequency range 1-10 MHz and the following results have been obtained: (1) About two-thirds of the total absorption arises at the macromolecular level, with the remainder caused by macroscopic structure. (2) The specific absorption of tissue macromolecules, as expressed in absorption per weight percent, varies considerably from one biopolymer to another. (3) The absorption is related to the structure of the biological macromolecule or its hydration and changes with heat denaturation and pH. (4) A similar frequency dependence results for all materials investigated. This dependence is to be expected if one assumes that the molecular processes of absorption are characterized by a broad spectrum of relaxational time constants and activation energies extending over a range of at least 1:7. |
| Title |
Mechanism of action of ultrasound on frog sciatic nerve. |
| Author |
Lonskiy AV. Makarov PO, Tuchkov BS. |
| Journal |
Tsitologiya |
| Volume |
|
| Year |
1969 |
| Abstract |
No abstract available. |
| Title |
Mechanism of cell damage by ultrasound in combination with hematoporphyrin. |
| Author |
Umemura S, Yumita N, Nishigaki R, Umemura K. |
| Journal |
Jpn J Cancer Res |
| Volume |
|
| Year |
1990 |
| Abstract |
The mechanism of cell damage by ultrasound in combination with hematoporphyrin was studied. Mouse sarcoma 180 cell suspensions were exposed to ultrasound for up to 60 s in the presence and absence of hematoporphyrin, with and without active oxygen scavengers. The cell damage enhancement by hematoporphyrin was suppressed by adding histidine but not by mannitol. The enhancement was doubled in rate by substitution of deuterium oxide medium for normal water. Sonoluminescence was produced in a saline solution under similar acoustic conditions and observed to have spectral components that can excite hematoporphyrin molecules. These results suggest that cell damage enhancement is probably mediated via singlet oxygen generated by ultrasonically activated hematoporphyrin. |
| Title |
Mechanism of intracellular delivery by acoustic cavitation. |
| Author |
Schlicher RK,Radhakrishna H,Tolentino TP,Apkarian RP,Zarnitsyn V,Prausnitz MR. |
| Journal |
Ultrasound Med Biol |
| Volume |
|
| Year |
2006 |
| Abstract |
Using conditions different from conventional medical imaging or laboratory cell lysis, ultrasound has recently been shown to reversibly increase plasma membrane permeability to drugs, proteins and DNA in living cells and animals independently of cell or drug type, suggesting a ubiquitous mechanism of action. To determine the mechanism of these effects, we examined cells exposed to ultrasound by flow cytometry coupled with electron and fluorescence microscopies. The results show that cavitation generated by ultrasound facilitates cellular incorporation of macromolecules up to 28 nm in radius through repairable micron-scale disruptions in the plasma membrane with lifetimes >1 min, which is a period similar to the kinetics of membrane repair after mechanical wounding. Further data suggest that cells actively reseal these holes using a native healing response involving endogenous vesicle-based membrane resealing. In this way, noninvasively focused ultrasound could deliver drugs and genes to targeted tissues, thereby minimizing side effects, lowering drug dosages, and improving efficacy. |
| Title |
Mechanism of low intensity ultrasound effect on mitochondria. |
| Author |
Selivanov VA, Zinchenko VP, Sarvazian AP. |
| Journal |
Biofizika |
| Volume |
|
| Year |
1982 |
| Abstract |
Ultrasound of 0.2 Wt/cm2 intensity affects the ionic transport across the mitochondrial membrane in vitro. In the presence of 1 mM EGTA in the incubation medium ultrasound slows down K+ exit into the external medium after the addition of an uncoupling agent (2,4-dinitrophenol). With the addition of 100 - 400 mM Ca2+ to the starting medium ultrasound makes the amount of Ca2+ absorbed by mitochondrial decrease and the rate of Ca2+/H+ electroneutral exchange increase. Without Ca2+ ultrasound does not influence the rate of coupled and 2,4-dinitrophenol uncoupled respiration and oxidative phosphorylation, i.e. does not produce strong functional changes. |
| Title |
Mechanisms by which low-intensity ultrasound improve tolernce to ischema-reperfusion injury. |
| Author |
Bertuglia S. |
| Journal |
Ultrasound Med Biol |
| Volume |
|
| Year |
2007 |
| Abstract |
Recent studies show that low-intensity ultrasound (US) increases endothelial nitric oxide (NO) levels in different models both in vitro and in vivo. Ischemia-reperfusion (I/R) injury is characterized by endothelial cell dysfunction, mainly as a result of altered shear stress responses associated with vasoconstriction, reduced capillary perfusion and excessive oxidative stress. This review provides an overview of the microvascular effects of low-intensity US and suggests that US exposure can be a method to provide tolerance to I/R damage. The hamster cheek pouch, extensively used in studies of I/R-induced injury, has been characterized in terms of changes of arteriolar diameter, flow and shear stress. The low-intensity US exposure reduces vasoconstriction and leukocyte adhesion and increases capillary perfusion during postischemic reperfusion. These effects may be the result of enhanced fluctuations in shear stress exerted by the flowing blood on the vessel wall. The fluctuations in turn are due to mechanical perturbations arising from the difference in acoustical impedance between the endothelial cells and the vessel content. We believe that periodic pulses of US may also cause a sustained reduction of oxidative stress and an enhanced endothelial NO level by increasing oscillatory shear stress during postischemic reperfusion. Low-intensity US exposure may represent a safe and novel important therapeutic target for patients with acute coronary syndromes and for treatment of chronic myocardial ischemia. |
| Title |
Mechanisms for attenuation in cancellous bone-mimicking phantoms. |
| Author |
Wear KA. |
| Journal |
IEEE Trans UFFC |
| Volume |
|
| Year |
2008 |
| Abstract |
Broadband ultrasound attenuation (BUA) in cancellous bone is useful for prediction of osteoporotic fracture risk, but its causes are not well understood. To investigate attenuation mechanisms, 9 cancellous-bone-mimicking phantoms containing nylon filaments (simulating bone trabeculae) embedded within soft-tissue-mimicking fluid (simulating marrow) were interrogated. The measurements of frequency-dependent attenuation coefficient had 3 separable components: 1) a linear (with frequency) component attributable to absorption in the soft-tissue-mimicking fluid, 2) a quasilinear (with frequency) component, which may include absorption in and longitudinal-shear mode conversion by the nylon filaments, and 3) a nonlinear (with frequency) component, which may be attributable to longitudinal-longitudinal scattering by the nylon filaments. The slope of total linear (with frequency) attenuation coefficient (sum of components #1 and #2) versus frequency was found to increase linearly with volume fraction, consistent with reported measurements on cancellous bone. Backscatter coefficient measurements in the 9 phantoms supported the claim that the nonlinear (with frequency) component of attenuation coefficient (component #3) was closely associated with longitudinal-longitudinal scattering. This work represents the first experimental separation of these 3 components of attenuation in cancellous bone-mimicking phantoms. |
Page 1
| 2
| 3
| 4
| 5
| 6
| 7
| 8
| 9
| 10
| 11
| 12
| 13
| 14
| 15
| 16
| 17
| 18
| 19
| 20
| 21
| 22
| 23
| 24
| 25
| 26
| 27
| 28
| 29
| 30
| 31
| 32
| 33
| 34
| 35
| 36
| 37
| 38
| 39
| 40
| 41
| 42
| 43
| 44
| 45
| 46
| 47
| 48
| 49
| 50
| 51
| 52
| 53
| 54
| 55
| 56
| 57
| 58
| 59
| 60
| 61
| 62
| 63
| 64
| 65
| 66
| 67
| 68
| 69
| 70
| 71
| 72
| 73
| 74
| 75
| 76
| 77
| 78
| 79
| 80
| 81
| 82
| 83
| 84
| 85
| 86
| 87
| 88
| 89
| 90
| 91
| 92
| 93
| 94
| 95
| 96
| 97
| 98
| 99
| 100
| 101
| 102
| 103
| 104
| 105
| 106
| 107
| 108
| 109
| 110
| 111
| 112
| 113
| 114
| 115
| 116
| 117
| 118
| 119
| 120
| 121
| 122
| 123
| 124
| 125
| 126
| 127
| 128
| 129
| 130
| 131
| 132
| 133
| 134
| 135
| 136
| 137
| 138
| 139
| 140
| 141
| 142
| 143
| 144
| 145
| 146
| 147
| 148
| 149
| 150
| 151
| 152
| 153
| 154
| 155
| 156
| 157
| 158
| 159
| 160
| 161
| 162
| 163
| 164
| 165
| 166
| 167
| 168
| 169
| 170
| 171
| 172
| 173
| 174
| 175
| 176
| 177
| 178
| 179
| 180
| 181
| 182
| 183
| 184
| 185
| 186
| 187
| 188
| 189
| 190
| 191
| 192
| 193
| 194
| 195
| 196
| 197
| 198
| 199
| 200
| 201
| 202
| 203
| 204
| 205
| 206
| 207
| 208
| 209
| 210
| 211
| 212
| 213
| 214
| 215
| 216
| 217
| 218
| 219
| 220
| 221
| 222
| 223
| 224
| 225
| 226
| 227
| 228
| 229
| 230
| 231
| 232
| 233
| 234
| 235
| 236
| 237
| 238
| 239
| 240
| 241
| 242
| 243
| 244
| 245
| 246
| 247
| 248
| 249
| 250
| 251
| 252
| 253
| 254
| 255
| 256
| 257
| 258
| 259
| 260
| 261
| 262
| 263
| 264
| 265
| 266
| 267
| 268
| 269
| 270
| 271
| 272
| 273
| 274
| 275
| 276
| 277
| 278
| 279
| 280
| 281
| 282
| 283
| 284
| 285
| 286
| 287
| 288
| 289
| 290
| 291
| 292
| 293
| 294
| 295
| 296
| 297
| 298
| 299
| 300
| 301
| 302
| 303
| 304
| 305
| 306
| 307
| 308
| 309
| 310
| 311
| 312
| 313
| 314
| 315
| 316
| 317
| 318
| 319
| 320
| 321
| 322
| 323
| 324
| 325
| 326
| 327
| 328
| 329
| 330
|
|
|
|
