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BRL Abstracts Database |
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Your search for ultrasound produced 3296 results. Page 309 out of 330
| Title |
Ultrasound focal beam surgery. |
| Author |
Ter Haar G. |
| Journal |
Ultrasound Med Biol |
| Volume |
|
| Year |
1995 |
| Abstract |
High intensity beams of ultrasound may be focused at depth within the body, thereby producing selective damage within the focal volume, with no harm to overlying or surrounding tissues. The technique is thus noninvasive, insofar as the source of ultrasound energy is situated outside the body. The mechanism for cell killing is predominantly thermal, although acoustic cavitation may also occur. Ultrasound focal surgery was first conceived in the 1940s as a possible tool for creating selective damage in the brain for neurosurgical research; its potential for more widespread clinical use was not exploited at that time, probably because of the lack of facilities for providing precise visualisation and localisation of the damage. The availability of modern imaging techniques has encouraged a revival of clinical interest, and applications in ophthalmology, urology and oncology are currently being developed. |
| Title |
Ultrasound for dentistry. |
| Author |
Jones SV. |
| Journal |
Sci Dig |
| Volume |
|
| Year |
1967 |
| Abstract |
No abstract available. |
| Title |
Ultrasound for drug and gene delivery to the brain. |
| Author |
Hynynen K. |
| Journal |
Adv Drug Deliv Rev |
| Volume |
|
| Year |
2008 |
| Abstract |
Noninvasive, transient, and local image-guided blood-brain barrier disruption (BBBD) has been demonstrated with focused ultrasound exposure in animal models. Most studies have combined low pressure amplitude and low time average acoustic power burst sonications with intravascular injection of pre-formed micro-bubbles to produce BBBD without damage to the neurons. The BBB has been shown to be healed within a few hours after the exposure. The combination of focused ultrasound beams with MR image guidance allows precise anatomical targeting as demonstrated by the delivery of several marker molecules in different animal models. This method may in the future have a significant impact on the diagnosis and treatment of central nervous system (CNS) disorders. Most notably, the delivery of the chemotherapy agents (liposomal Doxorubicin and Herceptin) has been shown in a rat model. |
| Title |
Ultrasound for identification of brain damage in infants and young children. |
| Author |
Heimburger RF, Fry FJ, Franklin TD Jr, Eggleton RC, Gresham E. |
| Journal |
Proc Twentieth Annu Meet AIUM |
| Volume |
|
| Year |
1975 |
| Abstract |
No abstract available. |
| Title |
Ultrasound for the induction of localized hyperthermia. |
| Author |
Hahn GM. |
| Journal |
Int J Radiat Oncol Biol Phys |
| Volume |
|
| Year |
1978 |
| Abstract |
No abstract available. |
| Title |
Ultrasound for the mediation of a therapeutic agent through the blood-brain barrier. |
| Author |
Bond LJ, Ng LK. |
| Journal |
J Acoust Soc Am |
| Volume |
|
| Year |
1998 |
| Abstract |
No Abstract Available. |
| Title |
Ultrasound for visualization and modification of brain tissue. |
| Author |
Fry FJ, Heimburger RF, Gibbons LV, Eggleton RC. |
| Journal |
IEEE J Sonics Ultrason |
| Volume |
|
| Year |
1970 |
| Abstract |
Techniques for the detailed, in vivo visualization and modification of internal brain structure via ultrasonic means have been developed and studied in both animal and man. The instrumentation used in these studies includes high-gain large-aperture ceramic transducers positioned in space by a specially adapted Cincinnati turret drill. Precise transducer positioning, amplifier gain, relief presentation, and other techniques are under on-line computer control; the system provides for the use of either simple, compound, or omnidirectional scanning modes. When the brain is viewed through an acoustically transparent window, essentially all soft-tissue fluid-filled space interfaces can be visualized, and in some instances gray-white matter interfaces can be seen clearly. Brain lesions produced by high-intensity focused ultrasound are tissue specific and can be shaped in vivo to conform with the complex geometry of a given brain structure. These ultrasonic lesions, as well as those produced by mechanical or electrolytic methods, can be visualized ultrasonically immediately after their placement. |
| Title |
Ultrasound heating in a tissue-bone phantom. |
| Author |
O'Neill TP, Winkler AJ, Wu J. |
| Journal |
Ultrasound Med Biol |
| Volume |
|
| Year |
1994 |
| Abstract |
Temperature rise generated by focused ultrasound beams was tested on semipermanent tissue-bone phantoms. The phantoms were capped (sealed) plastic hollow cylindrical containers filled with tissue-mimicking material (TMM), in which were imbedded 25 microns diameter copper-constantan thermocouples (TC) and a piece of compact human or cow bone. The acoustic frequency specific attenuation coefficient of TMM was adjusted to be 0.3 dB cm-1 MHz-1 as specified by the FDA for a frequency range of 1-5 MHz. A high density 0.318 cm thick polyethylene sheet was chosen as the material to make caps of the phantoms. A formula developed to estimate the upper limit of temperature rises at tissue-bone interfaces generated by focused ultrasound has been proved to be appropriate experimentally using the semipermanent phantoms. |
| Title |
Ultrasound heating in previously irradiated sites. |
| Author |
Marmor JB, Hahn GM. |
| Journal |
Int J Radiat Oncol Biol Phys |
| Volume |
|
| Year |
1978 |
| Abstract |
No abstract available. |
| Title |
Ultrasound image quality. |
| Author |
Snyder RA, Conrad RJ. |
| Journal |
Hewlett-Packard Journal |
| Volume |
|
| Year |
1983 |
| Abstract |
no abstract available. |
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