Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
 Tuesday, October 24th, 2017
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Bioengineering Research Partnership
William D. O'Brien, Jr. publications:

Michael L. Oelze publications:

Scanning Laser Acoustic Microscope Facility

A scanning laser acoustic microscope (Sonomicroscope 100) is available for examining on the micron scale the elastic properties of materials. For biological materials, the microscope's resolution is around 20 micrometers and is able to provide quantitative data in the form of ultrasonic attenuation and speed. The microscope is interfaced to a custom Z-80 based microcomputer such that images can be quantitatively analyzed and processed on a 486-based PC to yield the spatial distribution of the attenuation coefficient and speed of sound. The microscope computer system is able to digitize the microscope images with a 768 x 255 resolution. The 195,840 pixel image can be frame averaged up to 256 times with the 512 Kbytes of memory on the image digitizing system.


For more information on SLAM:

W. D. O'Brien, Jr., J. Olerud, J. M. Reid and K. K. Shung. Quantitative Acoustical Assessment of Wound Maturation with Acoustic Microscopy. Journal of the Acoustical Society of America, 69, 575-579, 1981.

M. A. McAvoy and W. D. O'Brien, Jr. Acoustic Velocity Using the Scanning Laser Acoustic Microscope (SLAM). Proceedings of the 1982 Ultrasonics Symposium, pp. 634-637, 1982.

P. M. Embree, S. G. Foster, G. Bright and W. D. O'Brien, Jr. Ultrasonic Velocity Spatial Distribution Analysis of Biological Materials with the Scanning Laser Acoustic Microscope. Acoustical Imaging, 13, 203-216, 1983.

K. M. U. Tervola, M. A. Grummer, J. W. Erdman, Jr. and W. D. O'Brien, Jr. Ultrasonic Attenuation and Velocity Properties in Rat Liver as a Function of Fat Concentration - A Study at 100 MHz using a Scanning Laser Acoustic Microscope. Journal of the Acoustical Society of America, 77, 307-313, 1985.

K. M. U. Tervola, S. G. Foster and W. D. O'Brien, Jr. Attenuation Coefficient Measurement Technique at 100 MHz with the Scanning Laser Acoustic Microscope. IEEE Transactions on Sonics and Ultrasonics, SU-32, 259-265, 1985.

P. M. Embree, K. M. U. Tervola, S. G. Foster and W. D. O'Brien, Jr. Spatial Distribution of the Speed of Sound in Biological Materials with the Scanning Laser Acoustic Microscope. IEEE Transactions Sonics and Ultrasonics, SU-32, 341-350, 1985.

C. A. Edwards and W. D. O'Brien, Jr. Speed of Sound in Mammalian Tendon Threads Using Reference Media. IEEE Transactions on Sonics and Ultrasonics, SU-32, 351-354, 1985.

K. M. U. Tervola and W. D. O'Brien, Jr. Spatial Frequency Domain Technique: An Approach to Analyze the Scanning Laser Acoustic Microscope. IEEE Transactions on Sonics and Ultrasonics, SU-32, 544-554, 1985.

K. M. U. Tervola, D. Steiger and W. D. O'Brien, Jr. Velocity and Attenuation Coefficient Measurement Techniques Using the Interferometric Mode of a 100 MHz Scanning Laser Acoustic Microscope. Proceedings Image Science '85, Acta nica Scandinavia, Applied Physics Series No. 150, Vol. 2, pp. 223-227, 1985.

J. A. Slobin, D. L. Stocum and W. D. O 'Brien, Jr. Amphibian Limb Regeneration Curves Generated by the Scanning Laser Acoustic Microscope. The Journal of Histochemistry and Cytochemistry, 34, 53-56, 1986.

J. E. Olerud, W. D. O'Brien, Jr., M. A. Riederer-Henderson, D. Steiger, F. K. Forster, C. Daly, D. J. Ketterer and G. F. Odland. Ultrasonic Assessment of Skin and Wounds with the Scanning Laser Acoustic Microscope. Journal of Investigative Dermatology, 88, 615-623, 1987.

W. D. O'Brien, Jr., J. W. Erdman, Jr. and T. B. Hebner. Ultrasonic Propagation Properties (@100 MHz) in Excessively Fatty Rat Liver. Journal of the Acoustical Society of America, 83, 1159-1167, 1988.

D. L. Steiger, W. D. O'Brien, Jr., J. E. Olerud, M. A. Riederer-Henderson and G. F. Odland. Measurement Uncertainty Assessment of the Scanning Laser Acoustic Microscope and Application to Canine Skin and Wound. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 35, 741-748, 1988.

M. A. Riederer-Henderson, J. E. Olerud, W. D. O'Brien, Jr., F. K. Forster, D. L. Steiger, D. J. Ketterer and G. F. Odland. Biochemical and Acoustical Parameters of Normal Canine Skin. IEEE Transactions on Biomedical Engineering, 35, 967-972, 1988.

C. M. W. Daft, G. A. D. Briggs and W. D. O'Brien, Jr. Frequency Dependence of Tissue Attenuation Measured by Acoustic Microscopy. Journal of the Acoustical Society of America, 85, 2194-2201, 1989.

W. L. Nyborg and W. D. O'Brien, Jr. An Alternative Simple Formula for Temperature Estimate. Journal of Ultrasound in Medicine, 8, 653-654, 1989.

J. E. Olerud, W. D. O'Brien, Jr., M. A. Riederer-Henderson, D. L. Steiger, J. Debel and G. F. Odland. Correlation of Tissue Constituents with the Acoustic Properties of Skin and Wound. Ultrasound in Medicine and Biology, 16, 55-64, 1990.

D. H. Agemura, W. D. O'Brien, Jr., J. E. Olerud, L. E. Chun and D. R. Eyre. Ultrasonic Propagation Properties of Articular Cartilage at 100 MHz. Journal of the Acoustical Society of America, 87, 1786-1791, 1990.

K. B. Sagar, D. H. Agemura, W. D. O'Brien, Jr., L. R. Pelc, T. L. Rhyne, L. S. Wann, R. A. Komorowski and D. C. Warltier. Quantitative Ultrasonic Assessment of Normal and Ischemic Myocardium with an Acoustic Microscope: Relationship to Integrated Backscatterer. Cardiovascular Research, 24, 447-455, 1990.

G. Scherba, P.A. Hoagland and W.D. O'Brien, Jr. Acoustic Microscopy: A Study of Contrast in Fresh Tissue. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 41, 451-457, 1994.

W. D. O'Brien, Jr., K. B. Sagar, D. C. Warltier and T. L. Rhyne. Acoustic Propagation Properties of Normal, Stunned and Infarcted Myocardium: Morphologic and Biochemical Determinants. Circulation, 91, 154-160, 1995.

P. D. O'Brien, W. D. O'Brien, Jr., T. L. Rhyne, D. C. Warltier and K. B. Sagar. Relationship of Ultrasonic Backscatter and Acoustic Propagation Properties to Myofibrillar Length and Myocardial Thickness, Circulation, 91, 171-175, 1995.

J. E. Assentoft, C. S. Joergensen, H. Gregersen, L. L. Christensen, J. C. Djurhuus and W. D. O'Brien, Jr. Characterizing Biological Tissue Using Scanning Laser Acoustic Microscopy. IEEE Engineering in Medicine and Biology Magazine, 15, 42-45, January/February, 1996.

A. A. Safvi, H. J. Meerbaum, S. A. Morris, C. L. Harper and W. D. O'Brien, Jr. Acoustic Imaging of Defects in Flexible Food Packages. Journal of Food Protection , 60, 309-314, 1997.



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